HCID 58169313, compound → HCID 50943863, compound

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Reaction Steps

The solution of 2-(2-(5-(N-tert-butylsulfamoyl)thiophen-2-yl)-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-5-yl)ethyl acetate (300 mg, 0.6 mmol) in CF3COOH (5 mL) was stirred at 60° C. After 1 h, the solution was evaporated to afford 2-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-(5-sulfamoylthiophen-2-yl)pyrimidin-5-yl)ethyl acetate (Compound 313) (250 mg, 93%). LC-MS (m/z)=449 [M+H]+; 1H NMR (400 MHz, DMSO-d6): δ 0.76 (m, 2H), 0.98-0.99 (m, 2H), 1.94 (m, 1H), 1.99 (s, 3H), 2.98 (s, 2H), 4.20 (s, 2H), 6.47 (s, 1H), 7.59 (s, 1H), 7.76 (d, J=2.8 Hz, 1H), 7.81 (s, 2H), 8.16 (s, 1H), 9.44 (s, 1H).

Provenance & Evidence