Acetic Anhydride → HCID 58169226, compound

Participants

Reaction Steps

To the mixture of ethyl 2-bromo-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidine-5-carboxylate (495 mg, 1.41 mmol) in THF (100 mL) and water (10 mL) was added Ac2O (2.0 mL). The reaction mixture was stirred for 2 h and water was added. The mixture was filtered and the solid was washed with water and concentrated with ethanol to remove the residual water to obtain ethyl 4-(1-acetyl-5-cyclopropyl-1H-pyrazol-3-ylamino)-2-bromopyrimidine-5-carboxylate (460 mg, 83%). LC-MS (m/z)=394.0 [M+H]+.

Provenance & Evidence