HCID 58169124, compound → HCID 58169510, compound

Participants

Reaction Conditions

Reaction Steps

At 20° C. (using an ice bath for the temperature control), 3-cyclopropyl-1H-pyrazol-5-amine (1.192 g, 9.68 mmol, 1.5 eq) in ethanol (15 ml) was added into a solution of compound 2,4-dibromo-6-methyl-5-((trimethylsilyl)ethynyl)pyrimidine (2.246 g, 6.45 mmol, 1.0 equiv.) in ethanol (15 mL). The reaction was stirred at for 20 h at 20-23° C. Ethanol was removed under reduced pressure 10-20° C. Purified by silica-gel column chromatography (mobile phase: petroleum ether/ethyl acetate=20/1; 5/1) afforded solid product 2-bromo-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-methyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-amine (500 mg, 22%). LC-MS (m/z)=392.0 [M+2H]+.

Provenance & Evidence