Potassium Carbonate → HCID 58169453, compound

Participants

Reaction Steps

The mixture of crude N-(5-(4-(1-acetyl-5-cyclopropyl-1H-pyrazol-3-ylamino)-5-ethynylpyrimidin-2-yl)thiophen-2-ylsulfonyl)acetamide and K2CO3 (43 mg, 0.31 mmol, 2.4 eq) in EtOH (10 mL) was stirred at room temperature for 1 h. The reaction mixture was filtered, the filtrate was concentrated. The residue was diluted with EtOAc and washed with water, brine, dried (Na2SO4), and filtered. The filtrate was concentrated and crystallized with ether to yield N-(5-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-ethynylpyrimidin-2-yl)thiophen-2-ylsulfonyl)acetamide (Compound 192) (65 mg, 84%). LC-MS (m/z)=429 [M+H]+; 1H NMR (400 MHz, DMSO-d6) δ 0.74-0.77 (m, 2H), 0.97-0.99 (m, 2H), 1.71 (s, 3H), 1.92-1.99 (m, 1H), 4.87 (s, 1H), 6.49 (s, 1H), 7.41 (d, J=4.0 Hz, 1H), 7.66 (d, J=3.6 Hz, 1H), 8.47 (s, 1H), 8.57 (bs, 1H), 12.31 (bs, 1H)

Provenance & Evidence