Sodium Acetate → 3-(5-Bromothiophen-2-yl)-3-oxopropyl acetate

Participants

Reaction Conditions

Reaction Steps

To the mixture of 1-(5-bromothiophen-2-yl)-3-chloropropan-1-one (2.8 g, 1.6 mmol, 1.0 eq), NaOAc (4.5 g, 55.3 mmol, 5 eq) and KI (200 mg) in acetic acid (16 mL) was stirred at 130° C. for overnight. The mixture was extracted with CH2Cl2 (3×40 ml). The combined organic layers were washed (brine), dried (Na2SO4), filtered and concentrated to give yellow oil 3-(5-bromothiophen-2-yl)-3-oxopropyl acetate (2.4 g, 76.2%). LC-MS (m/z)=278.1 [M+H]+

Provenance & Evidence