3-cyclopropyl-1H-pyrazol-5-amine → HCID 58169506, compound

Participants

Reaction Steps

A mixture of tert-butyl 2-(5-(4-bromo-5-chloropyrimidin-2-yl)thiophen-2-ylsulfonyl)hydrazinecarboxylate (179 mg, 0.38 mmol, 1.0 eq) and 5-cyclopropyl-1H-pyrazol-3-amine (92 mg, 0.76 mmol, 2.0 equiv.) in n-butanol was refluxed for 2 h, The reaction was cooled down and extracted with EA and the combined layers were dried (Na2SO4), filtered and purified by silica gel chromatography (EA/PE 1:2) to afford tert-butyl 2-(5-(5-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)thiophen-2-ylsulfonyl)hydrazinecarboxylate (23 mg, 12%). LC-MS (m/z)=512 [M+H]+.

Provenance & Evidence