HCID 58169506, compound → HCID 58169442, compound

Participants

Reaction Steps

Tert-butyl 2-(5-(5-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)thiophen-2-ylsulfonyl)hydrazinecarboxylate (23 mg, 0.05 mmol, 1.0 equiv.) was stirred in TFA at r.t. for 30 min. The reaction was concentrated and to the residue was added aqueous NaHCO3 and extracted with EA (3×). The combined EA layers were dried (Na2SO4), filtered, concentrated and washed with ether to afford the 5-(5-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)thiophene-2-sulfonohydrazide (Compound 251) (8 mg, 44%). LC-MS (m/z)=412 [M+H]+; 1H NMR (400 MHz, DMSO-d6): 0.75-0.76 (m, 2H), 0.98-0.99 (m, 2H), 1.91-1.95 (m, 1H), 4.23 (d, J=7.2 Hz, 2H), 6.41 (s, 1H), 7.94 (s, 1H), 8.30 (d, J=1.2 Hz, 1H), 8.46 (s, 2H), 9.47 (d, J=7.6 Hz, 1H), 12.37 (s, 1H).

Provenance & Evidence