Water → HCID 58169231, compound

Participants

Reaction Steps

A mixture of N-tert-butyl-5-(4-(5-tert-butyl-1H-pyrazol-3-ylamino)-5-chloropyrimidin-2-yl)thiophene-2-sulfonamide (95 mg, 0.22 mmol) and BCl3 (4 mL of 1N solution in DCM) in DCM (8 mL) was stirred for 0.5 h, After addition of water and extraction with EA (3×), the combined organic layers were dried (NaHSO4), filtered. The filtrate was concentrated to afford the title compound 5-(4-(5-tert-butyl-1H-pyrazol-3-ylamino)-5-chloropyrimidin-2-yl)thiophene-2-sulfonamide (C-236) (50 mg, 62%). LC-MS (m/z)=413 [M+H]+; 1H NMR (400 MHz, DMSO-d6): 1.34 (s, 9H), 6.57 (s, 1H), 7.58 (d, J=4.0 Hz, 1H), 7.75 (d, J=3.6 Hz, 1H), 7.81 (s, 2H), 8.47 (s, 1H), 9.52 (s, 1H).

Provenance & Evidence