HCID 178449967, compound → HCID 178514696, compound

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Reaction Steps

The solution of N-tert-butyl-5-(4-cyclopropyl-6-(3-cyclopropyl-1H-pyrazol-5-ylamino)pyrimidin-2-yl)thiophene-2-sulfonamide (50 mg, 0.1 mmol) in trifluoroacetic acid (5 mL) was stirred at 60° C. After 0.5 h, the solution was evaporated to give a residue which was recrystallized from ether to afford 5-(4-cyclopropyl-6-(3-cyclopropyl-1H-pyrazol-5-ylamino)pyrimidin-2-yl)thiophene-2-sulfonamide (VRCompound 298) (21 mg, 52%). LC-MS (m/z)=403.1 [M+H]+; δ (400 MHz, DMSO-d6); 0.71-0.74 (m, 2H), 0.93-1.02 (m, 6H), 1.88-2.00 (m, 2H), 6.19 (bs, 1H), 6.93 (bs, 1H), 7.46 (s, 2H), 8.01 (s, 1H), 8.14 (b, 1H), 9.86 (s, 1H).

Provenance & Evidence