HCID 178449968, compound → HCID 178514697, compound

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Reaction Steps

The solution of N-tert-butyl-5-(5-chloro-4-cyclopropyl-6-(3-cyclopropyl-1H-pyrazol-5-ylamino)pyrimidin-2-yl)thiophene-2-sulfonamide (60 mg, 0.12 mmol) in trifluoroacetic acid (5 mL) was stirred at 60° C. After 0.5 h, the solution was evaporated to give the crude product, which was recrystallized from ether to afford 5-(5-chloro-4-cyclopropyl-6-(3-cyclopropyl-1H-pyrazol-5-ylamino)pyrimidin-2-yl)thiophene-2 sulfonamide (Compound 304) (25 mg, 48%). LC-MS (m/z)=436.9 [M+H]+; δ (400 MHz, DMSO-d6); 0.73-0.77 (m, 2H), 0.96-0.99 (m, 2H), 1.12-1.14 (m, 4H), 1.91 (m, 1H), 2.43-2.47 (m, 1H), 6.39 (s, 1H), 7.48 (s, 2H), 7.96 (d, J=1.6 Hz, 1H), 8.18 (d, J=1.2 Hz, 1H), 9.18 (s, 1H)

Provenance & Evidence