HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → N-cyclopropylmethyl-4-(4-methoxy-phenylamino)-2-trifluoromethyl-benzensulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 4-bromo-N-(cyclopropylmethyl)-2-(trifluoromethyl)benzenesulfonamide | HCID 24948367 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-cyclopropylmethyl-4-(4-methoxy-phenylamino)-2-trifluoromethyl-benzensulfonamide | HCID 24948369 | 45% |
Reaction Steps
A mixture of 4-bromo-N-cyclopropylmethyl-2-trifluoromethylbenzenesulfonamide (295 mg, 0.82 mmol), 4-methoxyaniline (142 mg, 0.92 mmol), Pd(OAc)2 (26 mg, 0.11 mmol), BINAP (70 mg, 0.11 mmol) and cesium carbonate (395 mg, 1.21 mmol) in 15 ml toluene was relaxed for 6 hours. Toluene was evaporated in vacuum and crude oil was purified by Combiflash (PE-THF). Yield 45%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09422235B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-ba5ffaa6016642dc8290530c34189ca9 |
| Source note | uspto-grants-2016_08 |