Cesium carbonate → N-Cyclopropylmethyl-4-(4,6-dimethoxy-pyrimidin-2-ylamino)-2-trifluoromethyl-benzenesulfonamide

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Reaction Steps

Mixture of 4-bromo-N-cyclopropylmethyl-2-trifluoromethylbenzenesulfonamide (228 mg, 0.63 mmol), 2,-amino-4,6-dimethoxypyrimidine (156 mg, 1.0 mmol), Pd(OAc)2 (26 mg, 0.11 mmol), BINAP (78 mg, 0.12 mmol) and cesium carbonate (362 mg, 1.11 mmol) in 15 ml toluene was relaxed for 6 hours. Toluene was evaporated in vacuum and crude oil was purified by Combiflash (PE-THF). Yield 41%

Provenance & Evidence