Cyclohexylamine → HCID 24947994, compound

Participants

Reaction Steps

Mixture of 4-bromo-N-(tetrahydrofuran-2-ylmethyl)-2-trifluoromethylbenzenesulfonamide (200 mg, 0.51 mmol), cyclohexylamine (193 mg, 1.94 mmol), Pd(OAc)2 (22 mg, 0.10 mmol), BINAP (70 mg, 0.11 mmol) and cesium carbonate (340 mg, 1.01 mmol) in 15 ml toluene was relaxed for 6 hours. Toluene was evaporated in vacuum and crude oil was purified twice by Combiflash (PE-THF). Yield 29%

Provenance & Evidence