Cesium carbonate → n-Cyclopropylmethyl-4-[(6,6-dimethyl-bicyclo[3.1.1]hept-3-ylmethyl)-amino]-2-trifluoromethyl-benzenesulfonamide

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Reaction Steps

Mixture of 4-bromo-N-cyclopropylmethyl-2-trifluoromethylbenzenesulfonamide (200 mg, 0.55 mmol), (−)-cis-myrtanylamine (153 mg, 1.0 mmol), Pd(OAc)2 (26 mg, 0.1 mmol), BINAP (62 mg, 0.1 mmol) and cesium carbonate (401 mg, 1.26 mmol) in 15 ml toluene was relaxed for 6 hours. Toluene was evaporated in vacuum and crude oil was purified by Combiflash (PE-THF). Yield 42%

Provenance & Evidence