Methanol → Methyl 2-(benzyloxy)acetate

HRID 1485013Notes

Reaction equation

HRID 1485013 reaction equation
[CH2:1]([O:8][CH2:9][C:10](Cl)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:13][OH:14]>>[CH3:13][O:14][C:10](=[O:11])[CH2:9][O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 887MethanolHCID 177085Benzyloxyacetyl chloride

Product 1

HCID 11745225Methyl 2-(benzyloxy)acetate

Procedure

Benzyloxyacetyl chloride was added slowly to 10 vol of MeOH at 0-5° C. The mixture was stirred at room temperature for 20 h. MeOH was removed under vacuum to give quantitatively the desired product.

Workup

  1. customMeOH was removed under vacuum

Sources & evidence

ORD record
ord-2da2278fa5b04d86b776be03a5997935
Source dataset
uspto-grants-2016_08
Patent number
US09422282B2

Reaction notes

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