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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1485016Generated: October 31, 2026

Lawesson's reagent → HCID 86693571, compound

https://huagongshe.com/reaction/1485016

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLawesson's reagentHCID 87949—
ReactantHCID 67446824HCID 67446824—
SolventTolueneHCID 1140—
ProductHCID 86693571HCID 8669357150%

Reaction Steps

5-Benzyloxy-6-[5-(4-fluoro-benzyl)-[1,3,4]oxadiazol-2-yl]-3-methyl-3H-pyrimidin-4-one was treated with 0.62 equiv of Lawesson's reagent at 80-85° C. in toluene for 5-7 h. TLC showed one major product formation with some substrate still present. Chromatography (eluted with 70%-90% EtOAc/hexane) gave ˜50% yield of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09422282B2
Source datasetuspto-grants-2016_08
ORD IDord-77b2e4a66bf04da4be47b3b2efa3d3dd
Source noteuspto-grants-2016_08