HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 136336834, compound → HCID 136336833, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 136336834 | HCID 136336834 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 136336833 | HCID 136336833 | 68% |
Reaction Steps
5-Benzyloxy-6-[5-(4-fluoro-benzyl)-[1,3,4]oxadiazol-2-yl]-3-methyl-3H-pyrimidin-4-one oxime was hydrogenated at 1 atmosphere of hydrogen in the presence of equal weight of 10% Pd/C to give 68% yield of 6-[5-(4-fluoro-benzyl)-[1,3,4]oxadiazol-2-yl]-5-hydroxy-3-methyl-3H-pyrimidin-4-one oxime (COTI-HIV-1DOxime or, also referred to as COTI-HIV-1). Results are summarized below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09422282B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-ec7160d82ae54084af4c980c76e94bc3 |
| Source note | uspto-grants-2016_08 |