Trifluoroacetic acid methylene chloride → HCID 136080218, compound

HRID 1485018Notes

Reaction equation

HRID 1485018 reaction equation
C([O:8][C:9]1[C:10](=[O:29])[N:11]([CH3:28])[CH:12]=[N:13][C:14]=1[C:15]1[O:16][C:17]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)=[N:18][N:19]=1)C1C=CC=CC=1.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[F:27][C:24]1[CH:23]=[CH:22][C:21]([CH2:20][C:17]2[O:16][C:15]([C:14]3[N:13]=[CH:12][N:11]([CH3:28])[C:10](=[O:29])[C:9]=3[OH:8])=[N:19][N:18]=2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 67446824HCID 67446824, compound

Product 1

HCID 136080218HCID 136080218, compound

Procedure

Reaction of 5-benzyloxy-6-[5-(4-fluoro-benzyl)-[1,3,4]oxadiazol-2-yl]-3-methyl-3H-pyrimidin-4-one and a 1:1 mixture of TFA/CH2Cl2 gave the debenzylated product in reasonable yield. Results are summarized below.

Workup

  1. customgave the debenzylated product in reasonable yield
  2. customResults

Sources & evidence

ORD record
ord-bf73bc2c497c45a9906b9f40769a4d45
Source dataset
uspto-grants-2016_08
Patent number
US09422282B2

Reaction notes

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