関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Triethylsilane | HCID 12052 | — |
| 反応物 | (4-bromo-1-methyl-1H-pyrazol-5-yl)(phenyl)methanol | HCID 14520172 | — |
| 生成物 | 5-Benzyl-4-bromo-1-methyl-1H-pyrazole | HCID 86718547 | — |
反応手順
(4-Bromo-2-methyl-2H-pyrazol-3-yl)-phenyl-methanol (0.50 g; 1.87 mmol) was treated with 3.0 ml TFA and Triethylsilane (1.49 ml; 9.36 mmol) and heated to 50° C. for 16 hours. The product was purified via reversed phase chromatography under acid conditions.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09422290B2 |
|---|
| 出典データセット | uspto-grants-2016_08 |
|---|
| ORD ID | ord-6745875c38654367bf58562c63c818e5 |
|---|
| 出典メモ | uspto-grants-2016_08 |
|---|
