Acetic Acid → HCID 75201877, compound

Participants

Reaction Steps

N6-Benzyl-3,N6-dimethyl-N8-piperidin-4-yl-[1,2,4]triazolo[4,3-b]pyridazine-6,8-diamine (0.05 g; 0.11 mmol) was dissolved in 0.5 ml THF. Acetic acid (0.01 ml; 0.23 mmol), acetaldehyde (0.03 ml; 0.46 mmol) and STAB (0.03 g; 0.15 mmol) were added and stirred at ambient temperature for 3 hours. The crude material was purified by using reversed phase chromatography under basic conditions and afterwards by TLC.

Provenance & Evidence