反应详情

温度

40 °C

To a solution in ethanol (127 mL) of the compound (14.0 g) obtained in step (1) above, a Raney nickel catalyst (about 2.8 g) was added. In a hydrogen atmosphere, the mixture was stirred at room temperature for 12 hours and further stirred at 40° C. for 12 hours. After being cooled to room temperature, the reaction mixture was filtered through Celite (registered trademark) and the filtrate was concentrated under reduced pressure. The resulting precipitate was recovered by filtration and washed with ethanol. The filtrate was concentrated to give the titled compound as a red oil (13.4 g).

1. temperatureAfter being cooled to room temperature
2. filtrationthe reaction mixture was filtered through Celite (registered trademark)
3. concentrationthe filtrate was concentrated under reduced pressure
4. filtrationThe resulting precipitate was recovered by filtration
5. washwashed with ethanol
6. concentrationThe filtrate was concentrated