Styrene → 2-(4-Fluorophenyl)cyclopropane-1-carbaldehyde

HRID 1485083Notes

Reaction equation

C=CC1C=CC=CC=1.[F:9]C1C=CC(C=C)=CC=1.[C:18]1([C@H:24]2[CH2:26][C@H:25]2[CH2:27][OH:28])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[F:9][C:21]1[CH:22]=[CH:23][C:18]([CH:24]2[CH2:26][CH:25]2[CH:27]=[O:28])=[CH:19][CH:20]=1

Participants

Reactant 3

HCID 7501Styrene

HCID 678834-Fluorostyrene

HCID 11116214Ctk0G8678

Product 1

HCID 529828882-(4-Fluorophenyl)cyclopropane-1-carbaldehyde

Procedure

Instead of styrene, 4-fluorostyrene (10.0 g) was used and treated by the same techniques as in Reference Example 23-1(1) and (2) as well as Reference Example 19-1 to give the titled compound as a colorless oil (4.48 g).

Sources & evidence

ORD record: ord-7d71ce011f924418a57a4fcead8d6590
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09422240B2

Reaction notes

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