35793-87-4 → HCID 118113269, compound

HRID 1485127Notes

Reaction equation

[C:1](Cl)(C)(C)[CH3:2].NCC(O)=O.CCC1OC2C=CC(N)=CC=2C(=O)N1.[CH2:25](Cl)[CH3:26].NCC(O)=O.Cl[C:34]1[CH:62]=[CH:61][C:37]([O:38][C:39]2N=[CH:43][C:42]([CH2:45][N:46]3[CH2:51][CH2:50][C:49]([OH:52])=[C:48]([C:53]([NH:55][CH2:56][C:57]([OH:59])=[O:58])=[O:54])[C:47]3=[O:60])=[CH:41][CH:40]=2)=CC=1>>[CH:61]1([CH2:37][O:38][C:39]2[CH:40]=[CH:41][C:42]([CH2:45][N:46]3[CH2:51][CH2:50][C:49]([OH:52])=[C:48]([C:53]([NH:55][CH2:56][C:57]([O:59][CH2:1][CH3:2])=[O:58])=[O:54])[C:47]3=[O:60])=[CH:43][C:25]=2[CH3:26])[CH2:62][CH2:34]1

Participants

Reactant 4

HCID 3726335793-87-4

HCID 73052863TP0463518

HCID 86595916HCID 86595916, compound

HCID 88258111HCID 88258111, compound

Product 1

HCID 118113269HCID 118113269, compound

Procedure

Instead of the compound obtained in Reference Example A-1 and glycine tert-butyl hydrochloride, the compound (2.10 g) obtained in Reference Example A-302 and glycine ethyl hydrochloride (956 mg) were respectively used and treated by the same techniques as in Example 1-1(1) to (3) to give ethyl N-({1-[4-(cyclopropylmethoxy)-3-methylbenzyl]-4-hydroxy-2-oxo-1,2,5,6-tetrahydro-3-pyridinyl}carbonyl)glycinate as a yellow oil (2.01 g).

Sources & evidence

ORD record: ord-7fad1c6caf964ecc933e23b9cac17099
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09422240B2

Reaction notes

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