1H-Pyrazolo[3,4-d]pyrimidin-4-amine → HCID 178508725, compound

Participants

Reaction Conditions

Reaction Steps

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 30 (5.0 g, 37 mmol, 1 equiv) was suspended in DMF (100 mL) and N-iodosuccinimide (NIS) (10.7 g, 45 mmol, 1.2 equiv) was added. The reaction was heated at 80° C. for 2 hours. The reaction was cooled to room temperature and then to 0° C. and was quenched by the drop-wise addition of water (200 mL). The resulting solids were collected by filtration, washed with water and cold ethanol, and dried in a vacuum oven to yield 31 (8.1 g, 84% yield) as a beige solid.

Provenance & Evidence