Trifluoroacetic acid → 2-(6-(4-chlorophenyl)-1-methyl-5-oxo-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-4-yl)acetic acid

Participants

Reaction Steps

To a solution of tert-butyl 2-(6-(4-chlorophenyl)-1-methyl-5-oxo-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-4-yl)acetate (90 mg, 0.21 mmol) in 5 mL of DCM, was added TFA (1 mL). The mixture was stirred at room temperature for 2 h. The solvent was removed in vacuo and the residue was purified by flash chromatography eluting with DCM:MeOH=20:1 to give 2-(6-(4-chlorophenyl)-1-methyl-5-oxo-5,6-dihydro-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-4-yl)acetic acid as a yellow solid (68 mg, 87%). LRMS (M+H)+: 382 m/z.

Provenance & Evidence