反应详情

温度

40 °C

A mixture of 8-bromo-1-methyl-5,6-dihydrospiro[benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-4,1′-cyclopropane] (150 mg, 0.49 mmol) and palladium on carbon (40 mg) in methanol (10 mL) was stirred for 2 hours at 40° C. under hydrogen atmosphere. The solid was filtered and the filtrate was concentrated to give crude 1-methyl-5,6-dihydrospiro[benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine-4,1′-cyclopropane] (100 mg, 91%) as yellow oil, used for the next step without further purification. LRMS (M+H+)+: calcd 226.12. found 226.

1. filtrationThe solid was filtered
2. concentrationthe filtrate was concentrated