HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → N-(3-(4-amino-2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-(3-(4-Amino-2-(3,4,5-trimethoxyphenylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)-3-isopropylurea | HCID 53238196 | — |
| Reactant | 7-(3-Aminophenyl)-2-chlorothieno[3,2-d]pyrimidin-4-amine | HCID 86675655 | — |
| Product | N-(3-(4-amino-2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide | HCID 86675656 | 93.9% |
Reaction Steps
The target compound (360 mg, 93% yield) was prepared in the same manner as the synthesis of the compound of Example 12, using 7-(3-aminophenyl)-2-chlorothieno[3,2-d]pyrimidin-4-amine (300 mg, 1.08 mmol) and methanesulfonyl chloride (94 μL, 1.19 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09422307B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-8ee7edff6d704e788e9d63e6267047ab |
| Source note | uspto-grants-2016_08 |