反应详情

Intermediate 78 was coupled with 2-(3-chloro-phenyl)-ethylamine following procedure Q. The resulting product was deprotected following procedure R. LC-MS showed the product had the expected M+H+ of 442. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.30 (d, 1H), 8.18 (s, 2H), 7.66 (m, 2H), 7.12 (m, 4H), 4.49 (s, 2H), 3.63 (t, 2H), 3.24 (m, 4H), 2.98 (t, 2H), 2.90 (t, 2H), 2.08 (m, 2H), 1.36 (t, 3H).