4-Bromo-N-[methyl(oxo)pyrrolidin-1-yl-lambda6-sulfanylidene]aniline → (3R,3aR,6R,6aR)-6-({6-Chloro-5-[4-(4-{[methyl(oxo)pyrrolidin-1-yl-lambda6-sulfanylidene]amino}phenyl)phenyl]-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridin-2-yl}oxy)-hexahydrofuro[3,2-b]furan-3-ol

Participants

Reaction Steps

The title compound is prepared from (3R,3aR,6R,6aR)-6-(6-chloro-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazo[4,5-b]pyridin-2-yloxy)hexahydrofuro[3,2-b]furan-3-ol and 4-bromo-N-[methyl-(oxo)pyrrolidin-1-yl-λ6-sulfanylidene]aniline following a procedure analogous to that described for Intermediate 3 (Step 3). LC (method 1): tR=1.16 min; Mass spectrum (ESI+): m/z=726 [M+H]+.

Provenance & Evidence