N-[(4-Bromophenyl)(dimethylamino)oxo-lambda6-sulfanylidene]-2,2,2-trifluoroacetamide → N-({4-[4-(2-{[(3R,3aR,6R,6aR)-6-Hydroxy-hexahydrofuro[3,2-b]furan-3-yl]oxy}-6-chloro-3-{[2-(trimethylsilyl)ethoxy]methyl}imidazo[4,5-b]pyridin-5-yl)phenyl]phenyl}(dimethylamino)oxo-lambda6-sulfanylidene)-2,2,2-trifluoroacetamide

Participants

Reaction Steps

The title compound is prepared from (3R,3aR,6R,6aR)-6-(6-chloro-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazo[4,5-b]pyridin-2-yloxy)hexahydrofuro[3,2-b]furan-3-ol and N-[(4-bromophenyl)-(dimethylamino)oxo-λ6-sulfanylidene]-2,2,2-trifluoroacetamide following a procedure analogous to that described for Intermediate 3 (Step 3) using 1,4-dioxane as a solvent. LC (method 1): tR=1.22 min; Mass spectrum (ESI+): m/z=782 [M+H]+.

Provenance & Evidence