5-Bromo-2-iodopyrimidine → (3R,3aR,6R,6aR)-6-({5-[4-(5-Bromopyrimidin-2-yl)phenyl]-6-chloro-3-{[2-(trimethylsilyl)ethoxy]methyl}-3H-imidazo[4,5-b]pyridin-2-yl}oxy)-hexahydrofuro[3,2-b]furan-3-ol

Participants

Reaction Steps

The title compound is prepared from (3R,3aR,6R,6aR)-6-(6-chloro-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazo[4,5-b]pyridin-2-yloxy)hexahydrofuro[3,2-b]furan-3-ol and 5-bromo-2-iodopyrimidine following a procedure analogous to that described for Intermediate 3 (Step 3). LC (method 1): tR=1.28 min; Mass spectrum (ESI+): m/z=660, 662 [M+H]+.

Provenance & Evidence