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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1485651Generated: October 27, 2026

Trifluoroacetic acid → HCID 90101345, compound

https://huagongshe.com/reaction/1485651

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantTert-butyl 4-((4-((4-((2-(chloromethyl)allyl)oxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoateHCID 90102385—
SolventDichloromethaneHCID 6344—
ProductHCID 90101345HCID 9010134593.7%

Reaction Steps

To a solution of tert-butyl 4-((4-((4-((2-(chloromethyl)allyl)oxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate (1.3 g) in DCM (8 mL) was added TFA (3 ml). The mixture was stirred at room temperature for 3 hours. All the solvents were removed under vacuum to give 4-(4-(4-(2-(chloromethyl)allyloxy)benzylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoic acid (1.1 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09422311B2
Source datasetuspto-grants-2016_08
ORD IDord-ddf5e75bd7d747079aecfdb3ae5ae9a7
Source noteuspto-grants-2016_08