HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 90101345, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-((4-((4-((2-(chloromethyl)allyl)oxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate | HCID 90102385 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 90101345 | HCID 90101345 | 93.7% |
Reaction Steps
To a solution of tert-butyl 4-((4-((4-((2-(chloromethyl)allyl)oxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate (1.3 g) in DCM (8 mL) was added TFA (3 ml). The mixture was stirred at room temperature for 3 hours. All the solvents were removed under vacuum to give 4-(4-(4-(2-(chloromethyl)allyloxy)benzylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoic acid (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09422311B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-ddf5e75bd7d747079aecfdb3ae5ae9a7 |
| Source note | uspto-grants-2016_08 |