反应详情

To a 100 mL round-bottom flask equipped with a stir bar and charged with tert-butyl(3-(4-((4-((4-(3-bromopropoxy)-3-chlorobenzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate (1.655 g, 2.136 mmol) was added CH2Cl2 (5 mL), and then trifluoroacetic acid (2.50 mL, 32.4 mmol). The solution was stirred at room temperature for 2 h. The solution was transferred to a 250 mL separatory funnel and was diluted with EtOAc (75 mL). The solution was washed with sat. aq. NaHCO3 (75 mL). The aq. phase was extracted with EtOAc (2×75 mL). The combined organics were washed with sat. aq. NaCl (50 mL); dried over MgSO4; filtered; then concentrated in vacuo to afford N-(3-amino-2,2-dimethylpropyl)-4-((4-((4-(3-bromopropoxy)-3-chlorobenzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzamide trifluoroacetic acid as a colorless solid (1.52 g, 100%). MS m/z=674.25 (M+1)+.

1. customTo a 100 mL round-bottom flask equipped with a stir bar
2. customThe solution was transferred to a 250 mL separatory funnel
3. washThe solution was washed with sat. aq. NaHCO3 (75 mL)
4. extractionThe aq. phase was extracted with EtOAc (2×75 mL)
5. washThe combined organics were washed with sat. aq. NaCl (50 mL)
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. concentrationthen concentrated in vacuo