(S)-isopropyl 4-(cyclopropanecarbonyl)-3-methyl-7-(1H-pyrazol-4-yl)-3,4-dihydroquinoxaline-1(2H)-carboxylate → 4-Isopropyl 1-methyl (S)-2-methyl-6-(1H-pyrazol-4-yl)-2,3-dihydroquinoxaline-1,4-dicarboxylate
Reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12]([O:14][CH3:15])=[O:13])[C@@H:7]([CH3:16])[CH2:6][N:5]2[C:17]([O:19][CH:20]([CH3:22])[CH3:21])=[O:18].C1(C(N2C3C(=CC([C:38]4[CH:39]=[N:40][NH:41][CH:42]=4)=CC=3)N(C(OC(C)C)=O)C[C@@H]2C)=O)CC1>>[CH3:16][C@H:7]1[CH2:6][N:5]([C:17]([O:19][CH:20]([CH3:22])[CH3:21])=[O:18])[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([C:38]3[CH:39]=[N:40][NH:41][CH:42]=3)[CH:3]=2)[N:8]1[C:12]([O:14][CH3:15])=[O:13]Participants
3
Reactant 2
Product 1
Procedure
4-Isopropyl 1-methyl (S)-2-methyl-6-(1H-pyrazol-4-yl)-2,3-dihydroquinoxaline-1,4-dicarboxylate was synthesized from 4-isopropyl 1-methyl (S)-6-bromo-2-methyl-2,3-dihydroquinoxaline-1,4-dicarboxylate according to the procedure outlined above for (S)-isopropyl 4-(cyclopropanecarbonyl)-3-methyl-7-(1H-pyrazol-4-yl)-3,4-dihydroquinoxaline-1(2H)-carboxylate. MS (ESI, pos. ion) m/z 359 [M+1]+.
Sources & evidence
- ORD record
- ord-5b3893f7248b41908b6a2d570f110312
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09422281B2
Reaction notes
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