4-Carboxyphenylboronic Acid → (S)-4-(1-acetyl-4-(isopropoxycarbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl)benzoic acid

Participants

Role	Name	HCID	Charge
Reactant	4-Carboxyphenylboronic Acid	HCID 312183	—
Reactant	(S)-isopropyl 4-(cyclopropanecarbonyl)-3-methyl-7-(1H-pyrazol-4-yl)-3,4-dihydroquinoxaline-1(2H)-carboxylate	HCID 118079118	—
Reactant	HCID 118079263	HCID 118079263	—
Product	(S)-4-(1-acetyl-4-(isopropoxycarbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl)benzoic acid	HCID 118079542	—

Reaction Steps

(S)-4-(1-acetyl-4-(isopropoxycarbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl)benzoic acid was synthesized from (S)-isopropyl 4-acetyl-7-bromo-3-methyl-3,4-dihydroquinoxaline-1(2H)-carboxylate and 4-carboxyphenylboronic acid according to the procedure outlined above for (S)-isopropyl 4-(cyclopropanecarbonyl)-3-methyl-7-(1H-pyrazol-4-yl)-3,4-dihydroquinoxaline-1(2H)-carboxylate. MS (ESI, pos. ion) m/z 419 [M+Na]+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09422281B2
Source dataset	uspto-grants-2016_08
ORD ID	ord-b33bc3224afe4891be9d7ff3632075af
Source note	uspto-grants-2016_08