Ethyl chloroformate → HCID 118080487, compound

HRID 1485708Notes

Reaction equation

BrC1C=C2C(=CC=1)N(C(=O)C)[C@@H](C)CN2.ClC(OCC)=O.[C:22]([N:25]1[C:34]2[C:29](=[CH:30][C:31]([Br:35])=[CH:32][CH:33]=2)[N:28]([C:36]([O:38][CH:39](C)[CH3:40])=[O:37])[CH2:27][C@@H:26]1[CH3:42])(=[O:24])[CH3:23]>>[C:22]([N:25]1[C:34]2[C:29](=[CH:30][C:31]([Br:35])=[CH:32][CH:33]=2)[N:28]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH2:27][C@@H:26]1[CH3:42])(=[O:24])[CH3:23]

Participants

Reactant 3

HCID 10928Ethyl chloroformate

HCID 118078861(S)-1-(6-bromo-2-methyl-3,4-dihydroquinoxalin-1(2H)-yl)ethanone

HCID 118079263HCID 118079263, compound

Product 1

HCID 118080487HCID 118080487, compound

Procedure

Ethyl (S)-4-acetyl-7-bromo-3-methyl-3,4-dihydroquinoxaline-1 (2H)-carboxylate was prepared from (S)-1-(6-bromo-2-methyl-3,4-dihydroquinoxaline-1(2H)-yl)ethanone and ethyl chloroformate according to the procedure outlined above for (S)-isopropyl 4-acetyl-7-bromo-3-methyl-3,4-dihydroquinoxaline-1(2H)-carboxylate. MS (ESI, pos. ion) m/z 341, 343 [M+1]+.

Sources & evidence

ORD record: ord-102be0aa5b3844e4b405f69346d53919
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09422281B2

Reaction notes

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