HCID 118079933, compound → HCID 118080612, compound

HRID 1485795Notes

Reaction equation

[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([Br:15])=[C:11]([NH2:14])[CH:12]=2)[N:7]([C:16]([O:18][CH:19]([CH3:21])[CH3:20])=[O:17])[CH2:6][C@@H:5]1[CH3:22])(=[O:3])[CH3:2].[C:23](NC1C=C2C(=CC=1C1C=NN(C3CC3)C=1)N(C(OC(C)C)=O)C[C@H](C)N2C(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][C:10]=1[Br:15])[N:7]([C:16]([O:18][CH:19]([CH3:21])[CH3:20])=[O:17])[CH2:6][C@H:5]([CH3:22])[N:4]2[C:1](=[O:3])[CH3:2])(=[O:25])[CH3:24]

Participants

Reactant 2

HCID 118079933HCID 118079933, compound

HCID 118080534HCID 118080534, compound

Product 1

HCID 118080612HCID 118080612, compound

Procedure

Isopropyl (S)-6-acetamido-4-acetyl-7-bromo-3-methyl-3,4-dihydroquinoxaline-1(2H)-carboxylate was prepared from isopropyl (S)-4-acetyl-6-amino-7-bromo-3-methyl-3,4-dihydroquinoxaline-1(2H)-carboxylate according to the procedure described above for isopropyl (S)-6-acetamido-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-3,4-dihydroquinoxaline-1(2H)-carboxylate (Example 235). MS (ESI, pos. ion) m/z 412, 414 [M+H]+.

Sources & evidence

ORD record: ord-88abe462ec594eeab5d33209530994a7
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09422281B2

Reaction notes

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