Acetic Anhydride → HCID 118080635, compound

HRID 1485796Notes

Reaction equation

[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[C:15]1[CH:16]=[N:17][N:18]([CH:20]3[CH2:22][CH2:21]3)[CH:19]=1)[N:11]([C:23]([O:25][CH:26]([CH3:28])[CH3:27])=[O:24])[CH2:10][C@H:9]([CH3:29])[N:8]2[C:30](=[O:32])[CH3:31])(=[O:3])C.[C:33](OC(=O)C)(=[O:35])C>>[C:30]([N:8]1[C:7]2[C:12](=[CH:13][C:14]([C:15]3[CH:16]=[N:17][N:18]([CH:20]4[CH2:21][CH2:22]4)[CH:19]=3)=[C:5]([NH:4][C:1]([O:35][CH3:33])=[O:3])[CH:6]=2)[N:11]([C:23]([O:25][CH:26]([CH3:28])[CH3:27])=[O:24])[CH2:10][C@@H:9]1[CH3:29])(=[O:32])[CH3:31]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 118080534HCID 118080534, compound

Product 1

HCID 118080635HCID 118080635, compound

Procedure

Isopropyl (S)-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-6-((methoxycarbonyl)amino)-3-methyl-3,4-dihydroquinoxaline-1(2H)-carboxylate was synthesized according to the procedure described above for isopropyl (S)-6-acetamido-4-acetyl-7-(1-cyclopropyl-1H-pyrazol-4-yl)-3-methyl-3,4-dihydroquinoxaline-1(2H)-carboxylate (Example 235), substituting methyl chloroformate for acetic anhydride. MS (ESI, pos. ion) m/z 456 [M+H]+.

Sources & evidence

ORD record: ord-1fd78861b1cf4572aa8089099d5d02fa
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09422281B2

Reaction notes

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