Acetyl chloride → HCID 73295231, compound

Participants

Reaction Steps

A solution of acetyl chloride (552 mg, 500 μL, 7.03 mmol, Eq: 24.2) in MeOH (2 mL) was added to a vial containing ((S)-1-{(S)-1-Cyclohexyl-2-[(S)-1-(2,6-di fluoro-phenylcarbamoyl)-1,3-dihydro-iso indol-2-yl]-2-oxo-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester (174 mg, 291 μmol, Eq: 1.00). The mixture was stirred at RT for 1 h. The solvent was evaporated and the resulting solid was redissolved in MeCN (3 mL) and water (1 mL). It was lyophilized to give (S)-2-[(S)-2-Cyclohexyl-2-((S)-2-methylamino-propionylamino)-acetyl]-2,3-dihydro-1H-isoindole-1-carboxylic acid (2,6-difluoro-phenyl)-amide hydrochloride (148 mg) as a white powder, m/z=499 (M+H).

Provenance & Evidence