Acetyl chloride → HCID 73295401, compound

Participants

Reaction Steps

A solution of acetyl chloride (552 mg, 500 μL, 7.03 mmol, Eq: 74.3) in MeOH (2 mL) was added to a vial containing ((S)-1-{(S)-1-cyclohexyl-2-[(S)-1-(2,6-di fluoro-phenylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-2-oxo-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester (58 mg, 94.7 μmol, Eq: 1.00). The mixture was stirred at RT for 1 h. The solvent was evaporated and the resulting solid was dissolved in MeCN (3 mL) and water (1 mL) and the solution lyophilized to give (S)-2-[(S)-2-cyclohexyl-2-((S)-2-methylamino-propionylamino)-acetyl]-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2,6-difluoro-phenyl)-amide hydrochloride (50 mg) as a white powder (50 mg), m/z=513 (M+H).

Provenance & Evidence