Trifluoroacetic acid → HCID 131736767, compound

Participants

Reaction Steps

In a 50 mL pear-shaped flask, 6-chloro-1-(2,6-difluoro-phenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (0.6 g, 1.42 mmol, Eq: 1.00) was combined with DCM (25 mL) to give a light brown solution. TFA (4.85 g, 3.28 mL, 42.6 mmol, Eq: 30) was added. After 1 h, the reaction was concentrated, the residue dissolved in EtOAc and the mixture washed with 1 N NaOH and brine. The organic layer was dried over Na2SO4 and concentrated in vacuo to afford 0.3937 g 6-chloro-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2,6-difluoro-phenyl)-amide as a brown oil which was used without purification. 86.0% MS m/z 323.0 (M+H)

Provenance & Evidence