Trifluoroacetic acid → HCID 118252532, compound

Participants

Reaction Steps

To a solution of tert-butyl (S)-1-((S)-3-(2,6-difluorophenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-1-oxobutan-2-ylcarbamate (0.11 g, 226 μmol, Eq: 1.00) in DCM (2 mL) was added TFA (2.96 g, 2 mL, 26.0 mmol, Eq: 115) and the resulting solution was stirred at RT for 1 h. The reaction mixture was concentrated in vacuo and the residue azeotroped with n-heptanes to give (S)-2-((S)-2-amino-3-methylbutanoyl)-N-(2,6-difluorophenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide trifluoroacetate which was used without purification (0.11 g).

Provenance & Evidence