Hydrochloric Acid → HCID 73427079, compound

Participants

Reaction Steps

A rt solution of tert-butyl(S)-1-((2S,3S)-1-acetyl-2-methyl-5-((3-methylquinolin-4-yl)methyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylamino)-1-oxopropan-2-yl(methyl)carbamate (96 mg, 167 μmol) in 4 M HCl in dioxane (837 μl) was stirred for 1.5 h. The reaction was diluted with Et2O and the solids were collected by vacuum filtration, taken up in MeCN—H2O, and lyophilized to provide (S)-N-((2S,3S)-1-acetyl-2-methyl-5-((3-methylquinolin-4-yl)methyl)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide dihydrochloride (72.2 mg, 79%) as an off-white solid. MS m/z 474 (MH)+.

Provenance & Evidence