tert-Butyl piperazine-1-carboxylate → HCID 86722948, compound

HRID 1486154Notes

Reaction equation

HRID 1486154 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][CH2:3]1.[N:12]1([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>CO.[Pd]>[C:21]([O:20][C:18]([N:12]1[CH2:17][CH2:16][N:15]([CH:2]2[CH2:7][CH2:6][CH:5]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][CH2:3]2)[CH2:14][CH2:13]1)=[O:19])([CH3:24])([CH3:22])[CH3:23]

Participants

5

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 99204382-(4-oxocyclohexyl)acetic Acid

Product 1

HCID 86722948HCID 86722948, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 2-(4-oxocyclohexyl)acetic acid (0.576 g, 3.7 mmol) and tert-butyl piperazine-1-carboxylate (0.700 g, 3.7 mmol) in MeOH, was added Pd on carbon (80 mg), and the resultant reaction mixture was stirred under hydrogen atmosphere overnight. The catalyst was removed via filtration and the solvent was removed under reduced pressure to afford the acid as white solid (1.2 g. 99%).

Workup

  1. customthe resultant reaction mixture
  2. customThe catalyst was removed via filtration
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-fe2e8a554b774aa892f594024e8fea56
Source dataset
uspto-grants-2016_08
Patent number
US09422314B2

Reaction notes

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