HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178520737, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Propan-2-yl methanimidate--hydrogen chloride (1/1) | HCID 12801779 | — |
| Reactant | HCID 178511351 | HCID 178511351 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178520737 | HCID 178520737 | — |
Reaction Steps
To (R)-3-(2-(trans-4-(2-amino ethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid (Example 15) in MeOH was added DIEA (2.5 eq), followed by isopropyl formimidate hydrochloride (1.2 eq). The reaction mixture was stirred at RT overnight. The mixture was then concentrated in vacuo and the crude product was purified using reverse phase HPLC to afford the title compound. ESI-MS m/z 400 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09422314B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-fe352b97928b42d48e9e066a174bc8fb |
| Source note | uspto-grants-2016_08 |