Thionyl Chloride → 3-Iodo-2-methoxy-benzoyl chloride

HRID 1486181Notes

Reaction equation

HRID 1486181 reaction equation
[I:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:15])=O>>[I:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([Cl:15])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 121684323-Iodo-2-methoxybenzoic acid

Product 1

HCID 867229723-Iodo-2-methoxy-benzoyl chloride

Conditions

Temperature
82 °C

Procedure

To 3-iodo-2-methoxy-benzoic acid (8.29 g, 29.8 mmol) was added thionyl chloride (15 mL). The resulting solution was stirred for 2 minutes then heated to 82° C. and stirred at this temperature for 30 minutes. The solution was then concentrated under reduced pressure to give the title compound. This material was used without further purification.

Workup

  1. stirringstirred at this temperature for 30 minutes
  2. concentrationThe solution was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-daa4fe77befb488383dc64d10e0c2f9c
Source dataset
uspto-grants-2016_08
Patent number
US09422314B2

Reaction notes

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