Hydrochloric Acid → 4-(2-Benzyloxyethyl)cyclohexanone

Participants

Reaction Steps

A solution of 8-(2-(benzyloxy)ethyl)-1,4-dioxaspiro[4.5]decane (2.30 g, 8.32 mmol) in acetonitrile (18 mL) was added 6N HCl solution and the resulting solution was stirred at rt for 2 h. After removal of acetonitrile by evaporation, the residue was neutralized by solid NaHCO3, extracted with EtOAc, dried over Na2SO4. Filtration and evaporation to dryness gave the ketone as white solid (1.84 g, 95.5%).

Provenance & Evidence