HCID 90132492, compound → HCID 82306246, compound

Participants

Reaction Conditions

Reaction Steps

6.13 g of rac-tert-butyl [2-(3,4-difluorophenyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamate (Example 39A, purity about 60%, about 9.14 mmol) were initially charged in 13.1 ml of 40% aqueous methylamine solution, and the mixture was stirred in a closed vessel at 60° C. overnight. The reaction mixture was concentrated and the residue was purified by means of silica gel chromatography (eluent:dichloromethane:methanol:diethylamine 30:1:0.1; 20:1:0.1). 1.83 g of the title compound were obtained (74% of theory).

Provenance & Evidence