Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl trifluoromethyl ketone | HCID 9871 | — |
| Reactant | 2-Amino-2-phenylethanol | HCID 92466 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 66847496 | HCID 66847496 | — |
Reaction Steps
55.13 g (492.0 mmol) of 1,1,1-trifluoroacetone in toluene (1.35 l) were admixed with 45 g (328.0 mmol) of rac-2-amino-2-phenylethanol and 8.24 g (32.8 mmol) of pyridinium p-toluenesulphonate. The reaction mixture was boiled under reflux on a water separator for 16 h. The mixture was cooled to 0° C., and the solids formed were filtered off and dried under high vacuum. This gave 68.6 g (77% of theory, purity 85%) of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09422285B2 |
|---|
| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-d556e638ce164cf3833919bbeba18f12 |
|---|
| Source note | uspto-grants-2016_08 |
|---|
