Aluminium lithium hydride → HCID 73236150, compound

Participants

Reaction Conditions

Reaction Steps

31 g (120.0 mmol) of 3,3,3-trifluoro-2-[(2-hydroxy-1-phenylethyl)amino]-2-methylpropanonitrile from Example 48A were initially charged in tert-butyl methyl ether (3.1 l) and cooled to 0° C., 18.25 g (480.2 mmol) of lithium aluminium hydride were added and the reaction mixture was stirred at RT for 16 h. Subsequently, the mixture was cooled to 0° C., first quenched with 24 ml of water, then admixed with 24 ml of 15% aqueous potassium hydroxide solution and 48 ml of water. The resulting mixture was filtered through silica gel and washed with tert-butyl methyl ether. The organic phase was separated off, dried over sodium sulphate, filtered and concentrated. This gave 29.2 g (83% of theory, purity 89%) of the target compound.

Provenance & Evidence